Issues in Bone Infection, Biofilm and Bone Defect

June 11, 2014

Bone infection is known to be one of the major problems in orthopaedic surgery.

In combating bone infections our most obstinate opponents are not the the familiar plantonic pathogens but their phenotypically different sessile forms embedded in an extracellular matrix a BIOFILM.

Biofilm forms within minutes after contact with nonvital surfaces like implants or necrotic tissue. Biofilm embedded bacteria are protected from immunological defence and require much higher concentrations of antibiotics for elimination than their planktonic forms.

Once attaced to unvascularised surfaces biofilms are causing bone resorption and as a consequence loosening of implants. Prerequisite for cure therefore is complete removal of all implants and dead tissue.

Please follow this link to open the posterpresentation about the issues in bone infection, biofilm and bone defect. The poster shows more about the treatment and cure, untreated bonegraft are at risk to become contaminated, processed human allografts using gaseous solvents, antibiotic delivery and antibiotic impregnated allograft AiA.